James IV, King of Scotland (1488–1513), son and successor of James III. He was an able and popular king, and his reign was one of stability and progress for Scotland. After suppressing an insurrection of discontented nobles early in his rei...

Thomas Wolsey was an English political figure and cardinal of the Roman Catholic Church. When Henry VIII became king of England in 1509, Wolsey became the King's almoner. Wolsey's affairs prospered, and by 1514 he was the controlling figure...

Nicolaus Copernicus was a Renaissance- and Reformation-era mathematician and astronomer who formulated a model of the universe that placed the Sun rather than the Earth at the center of the universe, likely independently of Aristarchus of S...

Juan Ponce de León was a Spanish explorer and conquistador. He became the first Governor of Puerto Rico by appointment of the Spanish crown. He led the first known European expedition to La Florida, which he named during his first voyage to...

Isabella d'Este was marchesa of Mantua and one of the leading women of the Italian Renaissance and a major cultural and political figure. Isabella d'Este was well-educated in her youth in Ferrara, as her voluminous correspondence reveals. T...

Bartolomé de las Casas was a 16th-century Spanish historian, social reformer and Dominican friar. He became the first resident Bishop of Chiapas, and the first officially appointed "Protector of the Indians". His extensive writings, the mos...

Vasco Núñez de Balboa was a Spanish conquistador who founded the colony of Darién in Panama, the oldest extant European settlement in the mainland of the Americas. He crossed the Isthmus in search of gold, reaching the Pacific Ocean after a...

Pope Leo X, born Giovanni di Lorenzo de' Medici, was Pope from 9 March 1513 to his death in 1521. The second son of Lorenzo the Magnificent, ruler of the Florentine Republic, he was elevated to the cardinalate in 1489. He is probably bes...

Francisco Hernández de Córdoba is usually reputed as the founder of Nicaragua, and in fact he founded two important Nicaraguan cities, Granada and León. The currency of Nicaragua is named the córdoba in his memory. Cordoba was an officer of...

Diego de Almagro, also known as El Adelantado and El Viejo (The Elder), was a Spanish conquistador and a companion and later rival of Francisco Pizarro. He participated in the Spanish conquest of Peru and is credited as the first European d...

Francisco Pizarro was a Conquistador who seized the Inca empire for Spain. In 1510 he enrolled in an expedition of exploration in the New World, and three years later he joined Vasco Núñez de Balboa on the expedition that discovered the Pac...

Michelangelo Buonarroti was an Italian sculptor, painter, architect, poet, and engineer of the High Renaissance who exerted an unparalleled influence on the development of Western art. Despite making few forays beyond the arts, his versatil...

Juan Sebastián Elcano was a Basque navigator, subject of the Kingdom of Castile. He is best known for completing the first world circumnavigation in History. Elcano was a naval commander subject of Charles I of Castile and he completed the...

Louise of Savoy was a French noble, Duchess regnant of Auvergne and Bourbon, Duchess of Nemours, the mother of King Francis I of France. She was politically active and served as the Regent of France in 1515, in 1525–1526 and in 1529....

Giorgione was an Italian painter of the Venetian school in the High Renaissance from Venice, whose career was cut off by his death at a little over 30. Giorgione is known for the elusive poetic quality of his work, though only about six sur...